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Article

PNPLA3 in Alcohol-Related Liver Disease.

Liver international : official journal of the International Association for the Study of the Liver - 1 Jan 2025

Galvanin Clélia, Buch Stephan, Nahon Pierre, Trépo Eric

Abstract excerpt

The discovery of PNPLA3 as a genetic risk factor for liver disease has transformed our understanding of the pathogenesis of alcohol-related liver disease (ALD). The recent reclassification of fatty liver disease as steatotic liver disease (SLD), introducing metabolic dysfunction and alcohol-related liver disease (MetALD), has highlighted how genetic and environmental factors synergistically drive liver damage....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39679853
DOI: 10.1111/liv.16211

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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PNPLA3 in Alcohol-Related Liver Disease.PMID 39679853Read ↗

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Genetics of alcoholic liver disease and non-alcoholic steatohepatitis.Semantic proximity Read ↗

[The role of the PNPLA3 gene rs738409 variant in the spectrum of metabolic dysfunction associated steatotic liver diseases].Semantic proximity Read ↗

Genetics in Common Liver Diseases: From Pathophysiology to Precise Treatment.Semantic proximity Read ↗

Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD.Semantic proximity Read ↗

MetALD: Genetic Factors and Clinical Outcomes.Semantic proximity Read ↗

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics.Semantic proximity Read ↗

Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis CSemantic proximity Read ↗

An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis.Semantic proximity Read ↗

PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers.Semantic proximity Read ↗

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