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Article

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.

Human genetics - 1 Jul 2012

Zain Shamsul Mohd, Mohamed Rosmawati, Mahadeva Sanjiv, Cheah Phaik Leng, Rampal Sanjay, Basu Roma Choudhury, Mohamed Zahurin

Abstract excerpt

The adiponutrin (PNPLA3) rs738409 polymorphism has been found to be associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in various cohorts. We further investigated the association of this polymorphism with non-alcoholic steatohepatitis (NASH) severity and with histological features of NAFLD. A total of 144 biopsy-proven NAFLD patients and 198 controls were genotyped for PNPLA3 gene...

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Body Mass Index
Fatty Liver
Lipase
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Cirrhosis

Membrane Proteins

Non-alcoholic Fatty Liver Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 22258181
DOI: 10.1007/s00439-012-1141-y
PMCID: PMC3374090

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.PMID 22258181Read ↗

Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.Semantic proximity Read ↗

PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease.Semantic proximity Read ↗

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severitySemantic proximity Read ↗

Association Between the PNPLA3 rs738409 Polymorphism and Susceptibility to Non-Alcoholic Fatty Liver Disease: A Systematic Review and Ethnicity-Stratified Meta-analysisSemantic proximity Read ↗

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.Semantic proximity Read ↗

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 rs738409 I748M is associated with steatohepatitis in 434 non-obese subjects with hepatitis C.Semantic proximity Read ↗

The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis.Semantic proximity Read ↗

Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.Semantic proximity Read ↗

PNPLA3 polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis.Semantic proximity Read ↗

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