Article
From genes to proteins in mendelian Parkinson's disease: an overview.
Anatomical record (Hoboken, N.J. : 2007) - 1 Dec 2009
Pirkevi Caroline, Lesage Suzanne, Brice Alexis, Başak A Nazli
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. A progressive movement disorder typified by the production of bradykinesia, tremor, rigidity, and impairment of postural reflexes, PD is characterized by a depletion of dopamine in the striatum. For the last decade, several Mendelian forms of PD have been identified. Mutations in these genes potentially lead...
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