Article
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.
Journal of neurochemistry - 1 Oct 2016
Hernandez Dena G, Reed Xylena, Singleton Andrew B
Abstract excerpt
Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with resting tremor, postural instability, rigidity, bradykinesia, and a good response to levodopa therapy. Over the last 15 years, numerous studies have confirmed that genetic factors contribute to the complex pathogenesis of PD. Highly...
Topics
- Animals
- Genome-Wide Association Study
- Humans
- Mutation
- Parkinson Disease
- Ubiquitin-Protein Ligases
- alpha-Synuclein