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Article

What genetics tells us about the causes and mechanisms of Parkinson's disease.

Physiological reviews - 1 Oct 2011

Corti Olga, Lesage Suzanne, Brice Alexis

Abstract excerpt

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the progressive degeneration of the dopaminergic neurons of the substantia nigra and is accompanied by the appearance of intraneuronal inclusions enriched in α-synuclein, the Lewy bodies. It is becoming increasingly clear that genetic factors contribute to its complex pathogenesis. Over the past decade, the genetic basis of...

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PMID: 22013209
DOI: 10.1152/physrev.00022.2010

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PINK1

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