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Article

Role of mendelian genes in "sporadic" Parkinson's disease.

Parkinsonism & related disorders - 1 Jan 2012

Lesage Suzanne, Brice Alexis

Abstract excerpt

The molecular mechanisms underlying neuronal degeneration leading to Parkinson's disease (PD) remain unknown. However, it is becoming increasingly clear that genetic factors contribute to its complex pathogenesis. In the past 15 years, the genetic basis of rare forms of PD with Mendelian inheritance, which represent no more than 10% of the cases, has been investigated. More than 18 loci, identified through...

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Identifiers

PMID: 22166458
DOI: 10.1016/S1353-8020(11)70022-0

Genes

PINK1
PTEN
SNCA
VPS35

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