Article
Genetics of Parkinson's disease.
Minerva medica - 1 Jun 2005
Bonifati V
Abstract excerpt
The past few years, mutations in 5 genes (a-synuclein, parkin, DJ-1, PINK1, and LRRK2) have been firmly implicated, and additional chromosomal loci have been mapped for inherited forms of Parkinson's disease (PD). These discoveries have profound implications for both the scientific and clinical communities. First, although some of the Mendelian forms of PD are very rare (including those caused by alfa-synuclein,...
Topics
- Chromosome Mapping
- Genetic Predisposition to Disease
- Humans
- Intracellular Signaling Peptides and Proteins
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Oncogene Proteins
- Parkinson Disease
- Protein Deglycase DJ-1
- Protein Kinases
- Protein Serine-Threonine Kinases
- Ubiquitin-Protein Ligases
- alpha-Synuclein