Article
An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
Human molecular genetics - 15 Feb 2010
Fairfax Benjamin P, Vannberg Fredrik O, Radhakrishnan Jayachandran, Hakonarson Hakon, Keating Brendan J, Hill Adrian V S, Knight Julian C
Abstract excerpt
Interleukin-6 (IL-6) is an important modulator of inflammation and immunity whose dysregulation is associated with a number of disease states. There is evidence of significant heritability in inter-individual variation in IL6 gene expression but the genetic variants responsible for this remain to be defined. We adopted a combined approach of mapping protein and expression quantitative trait loci in peripheral...
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