Article
Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping.
Genome research - 1 Jan 2007
Forton Julian T, Udalova Irina A, Campino Susana, Rockett Kirk A, Hull Jeremy, Kwiatkowski Dominic P
Abstract excerpt
It appears that, for many genes, the two alleles possessed by an individual may produce different amounts of transcript. When such allelic differences in transcription are observed for some individuals but not others, a plausible explanation is genetic variation in the cis-acting elements that regulate the gene in question. Here we describe a novel analytical approach that uses such observations, combined with...
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