Article
Cytokine and Oxylipin Production in Resting and LPS-Stimulated Monocytes From Americans of African Ancestry Are Influenced by ALOX5 Promoter Tandem Repeat Polymorphisms.
Mediators of inflammation - 1 Jan 2026
Snodgrass Ryan G, Stephensen Charles B, Armstrong Patrice, Allayee Hooman, Snodgrass Isabel F, Laugero Kevin D, Newman John W
Abstract excerpt
The arachidonate 5-lipoxygenase (ALOX5) specificity protein 1 (Sp1) promoter tandem repeat polymorphism is associated with enhanced cardiovascular disease (CVD) risk. However, a functional understanding of these variants in immune cells central to disease development remains limited. We investigated oxylipin and cytokine production in resting and lipopolysaccharide (LPS)-stimulated CD14+ monocytes from...
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