Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

doi:10.1086/513206

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Article

Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

American journal of human genetics - 1 Apr 2007

Reich David, Patterson Nick, Ramesh Vijaya, De Jager Philip L, McDonald Gavin J, Tandon Arti, Choy Edwin, Hu Donglei, Tamraz Bani, Pawlikowska Ludmila, Wassel-Fyr Christina, Huntsman Scott, Waliszewska Alicja, Rossin Elizabeth, Li Rongling, Garcia Melissa, Reiner Alexander, Ferrell Robert, Cummings Steve, Kwok Pui-Yan, Harris Tamara, Zmuda Joseph M, Ziv Elad

Abstract excerpt

Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study. Using admixture mapping, we found a significant association of interleukin 6 soluble receptor (IL-6 SR) with European...

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PMID: 17357077
DOI: 10.1086/513206
PMCID: PMC1852718

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