Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.

doi:10.1371/journal.pgen.1001213

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Article

Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.

PLoS genetics - 18 Nov 2010

Marzi Carola, Albrecht Eva, Hysi Pirro G, Lagou Vasiliki, Waldenberger Melanie, Tönjes Anke, Prokopenko Inga, Heim Katharina, Blackburn Hannah, Ried Janina S, Kleber Marcus E, Mangino Massimo, Thorand Barbara, Peters Annette, Hammond Christopher J, Grallert Harald, Boehm Bernhard O, Kovacs Peter, Geistlinger Ludwig, Prokisch Holger, Winkelmann Bernhard R, Spector Tim D, Wichmann H-Erich, Stumvoll Michael, Soranzo Nicole, März Winfried, Koenig Wolfgang, Illig Thomas, Gieger Christian

Abstract excerpt

Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies. To investigate the genetic basis of A-SAA levels, we conducted the first genome-wide association study on baseline A-SAA concentrations in three population-based studies (KORA, TwinsUK, Sorbs) and one prospective case...

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PMID: 21124955
DOI: 10.1371/journal.pgen.1001213
PMCID: PMC2987930

Genes

CRP
HPS5
LDHA
LDHC
LEPR
SAA1

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