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Article

A nine amino acid domain is essential for mutant prion protein toxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Sept 2011

Westergard Laura, Turnbaugh Jessie A, Harris David A

Abstract excerpt

Transgenic mice expressing prion protein (PrP) molecules with several different internal deletions display spontaneous neurodegenerative phenotypes that can be dose-dependently suppressed by coexpression of wild-type PrP. Each of these deletions, including the largest one (Δ32-134), retains 9 aa immediately following the signal peptide cleavage site (residues 23-31; KKRPKPGGW). These residues have been implicated...

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Identifiers

PMID: 21957261
DOI: 10.1523/JNEUROSCI.1243-11.2011
PMCID: PMC3227396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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