Article
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
The Journal of biological chemistry - 31 Dec 2004
Drisaldi Bettina, Coomaraswamy Janaky, Mastrangelo Peter, Strome Bob, Yang Jing, Watts Joel C, Chishti M Azhar, Marvi Melissa, Windl Otto, Ahrens Rosemary, Major François, Sy Man-Sun, Kretzschmar Hans, Fraser Paul E, Mount Howard T J, Westaway David
Abstract excerpt
The PrP-like Doppel (Dpl) protein causes apoptotic death of cerebellar neurons in transgenic mice, a process prevented by expression of the wild type (wt) cellular prion protein, PrP(C). Internally deleted forms of PrP(C) resembling Dpl such as PrPDelta32-121 produce a similar PrP(C)-sensitive pro-apoptotic phenotype in transgenic mice. Here we demonstrate that these phenotypic attributes of wt Dpl, wt PrP(C),...
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