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Article

Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.

Carcinogenesis - 1 Aug 2007

Curtin Karen, Slattery Martha L, Ulrich Cornelia M, Bigler Jeannette, Levin Theodore R, Wolff Roger K, Albertsen Hans, Potter John D, Samowitz Wade S

Abstract excerpt

This study investigated associations between CpG island methylator phenotype (CIMP) colon cancer and genetic polymorphisms relevant to one-carbon metabolism and thus, potentially the provision of methyl groups and risk of colon cancer. Data from a large, population-based case-control study (916 i...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17449906
DOI: 10.1093/carcin/bgm089
PMCID: PMC2442467

Genes

MTHFR
DHFR
MLH1
MTHFD1
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17449906-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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