Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.

doi:10.1371/journal.pone.0007786

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Article

Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.

PloS one - 11 Nov 2009

Katayama Kei-ichi, Zine Azel, Ota Maya, Matsumoto Yoshifumi, Inoue Takashi, Fritzsch Bernd, Aruga Jun

Abstract excerpt

Slitrks are type I transmembrane proteins that share conserved leucine-rich repeat domains similar to those in the secreted axonal guidance molecule Slit. They also show similarities to Ntrk neurotrophin receptors in their carboxy-termini, sharing a conserved tyrosine residue. Among 6 Slitrk family genes in mammals, Slitrk6 has a unique expression pattern, with strong expression in the sensory epithelia of the...

Topics

Animals
Cochlea
Ear, Inner
Ganglia
Ganglia, Spinal
Gene Expression Regulation, Developmental
In Situ Hybridization
Membrane Proteins
Mice
Mice, Knockout
Neurons
Open Reading Frames
Phenotype
Phosphorylation
Time Factors

Source

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Identifiers

PMID: 19936227
DOI: 10.1371/journal.pone.0007786
PMCID: PMC2777407

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