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Article

Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Oct 2004

Stankovic Konstantina, Rio Carlos, Xia Anping, Sugawara Mitsuru, Adams Joe C, Liberman M Charles, Corfas Gabriel

Abstract excerpt

Degeneration of cochlear sensory neurons is an important cause of hearing loss, but the mechanisms that maintain the survival of adult cochlear sensory neurons are not clearly defined. We now provide evidence implicating the neuregulin (NRG)-erbB receptor signaling pathway in this process. We found that NRG1 is expressed by spiral ganglion neurons (SGNs), whereas erbB2 and erbB3 are expressed by supporting cells...

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Share to Cochlea
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hair Cells, Auditory

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Share to Neurons, Afferent

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Share to Receptor, ErbB-4

Source

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Identifiers

PMID: 15470130
DOI: 10.1523/JNEUROSCI.0733-04.2004
PMCID: PMC6729966

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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