Article
Mice lacking brain-derived neurotrophic factor develop with sensory deficits.
Nature - 10 Mar 1994
Ernfors P, Lee K F, Jaenisch R
Abstract excerpt
During vertebrate development, neuronal survival depends on target-derived neurotrophic factors. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro, and of central motor neurons as well as dopamine...
Topics
- Animals
- Animals, Newborn
- Brain-Derived Neurotrophic Factor
- Cell Death
- Cell Line
- Ear, Inner
- Embryo, Mammalian
- Embryonic and Fetal Development
- Ganglia
- Mice
- Mice, Inbred BALB C
- Mice, Mutant Strains
- Movement Disorders
- Mutation
- Nerve Tissue Proteins
- Nervous System
- Neurons, Afferent
- Peripheral Nervous System