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Article

Mice lacking brain-derived neurotrophic factor develop with sensory deficits.

Nature - 10 Mar 1994

Ernfors P, Lee K F, Jaenisch R

Abstract excerpt

During vertebrate development, neuronal survival depends on target-derived neurotrophic factors. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development. It also prevents the death of motor neurons and...

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Source

Identifiers

PMID: 8139657
DOI: 10.1038/368147a0

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits.PMID 8139657Read ↗

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Semantic proximity Read ↗

Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice.Semantic proximity Read ↗

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5.Semantic proximity Read ↗

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.Semantic proximity Read ↗

Complementary roles of BDNF and NT-3 in vestibular and auditory development.Semantic proximity Read ↗

Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.Semantic proximity Read ↗

Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning.Semantic proximity Read ↗

Role of neurotrophins in mouse neuronal development.Semantic proximity Read ↗

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BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons.Semantic proximity Read ↗

Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.Semantic proximity Read ↗

Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets.Semantic proximity Read ↗

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