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Article

Complementary roles of BDNF and NT-3 in vestibular and auditory development.

Neuron - 1 Jun 1995

Ernfors P, Van De Water T, Loring J, Jaenisch R

Abstract excerpt

The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 d...

Topics

Afferent Pathways
Animals
Brain-Derived Neurotrophic Factor
Cochlea
Efferent Pathways
Hair Cells, Auditory
Immunohistochemistry
Mice
Mutation
Nerve Growth Factors
Nerve Tissue Proteins
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurotrophin 3

Vestibule, Labyrinth

Source

Identifiers

PMID: 7605630
DOI: 10.1016/0896-6273(95)90263-5

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7605630-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Complementary roles of BDNF and NT-3 in vestibular and auditory development.PMID 7605630Read ↗

Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice.Semantic proximity Read ↗

Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression.Semantic proximity Read ↗

A role for BDNF in early postnatal rat vestibular epithelia maturation: implication of supporting cells.Semantic proximity Read ↗

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Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.Semantic proximity Read ↗

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.Semantic proximity Read ↗

Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.Semantic proximity Read ↗

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5.Semantic proximity Read ↗

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Semantic proximity Read ↗

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Neurotrophin-3 is a survival factor in vivo for early mouse trigeminal neurons.Semantic proximity Read ↗

Defects in sensory organ morphogenesis and generation of cochlear hair cells in Gata3-deficient mouse embryos.Semantic proximity Read ↗

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