Article
Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1.
Developmental biology - 15 Nov 2011
Huettl Rosa-Eva, Huber Andrea B
Abstract excerpt
Interaction of the axon guidance receptor Neuropilin-1 (Npn-1) with its repulsive ligand Semaphorin 3A (Sema3A) is crucial for guidance decisions, fasciculation, timing of growth and axon-axon interactions of sensory and motor projections in the embryonic limb. At cranial levels, Npn-1 is expressed in motor neurons and sensory ganglia and loss of Sema3A-Npn-1 signaling leads to defasciculation of the superficial...
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