Article
Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice.
Development (Cambridge, England) - 1 Jun 1996
Bianchi L M, Conover J C, Fritzsch B, DeChiara T, Lindsay R M, Yancopoulos G D
Abstract excerpt
The generation of mice lacking specific neurotrophins permits evaluation of the trophic requirements of particular neuronal populations throughout development. In the present study, we examined the developing vestibulocochlear system to determine the time course of neurotrophin dependence and to...
Topics
- Animals
- Brain-Derived Neurotrophic Factor
- Cochlea
- Ganglia, Sensory
- Heterozygote
- Homozygote
- Mice
- Mutation
- Nerve Degeneration
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons
- Vestibule, Labyrinth