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Article

Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets.

Development (Cambridge, England) - 1 Oct 1995

Schimmang T, Minichiello L, Vazquez E, San Jose I, Giraldez F, Klein R, Represa J

Abstract excerpt

The trkB and trkC genes are expressed during the formation of the vestibular and auditory system. To elucidate the function of trkB and trkC during this process, we have analysed mice carrying a germline mutation in the tyrosine kinase catalytic domain of these genes. Neuroanatomical analysis of homozygous mutant mice revealed neuronal deficiencies in the vestibular and cochlear ganglia. In trkB (-/-) animals...

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Identifiers

PMID: 7588071
DOI: 10.1242/dev.121.10.3381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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