Article
Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets.
Development (Cambridge, England) - 1 Oct 1995
Schimmang T, Minichiello L, Vazquez E, San Jose I, Giraldez F, Klein R, Represa J
Abstract excerpt
The trkB and trkC genes are expressed during the formation of the vestibular and auditory system. To elucidate the function of trkB and trkC during this process, we have analysed mice carrying a germline mutation in the tyrosine kinase catalytic domain of these genes. Neuroanatomical analysis of...
Topics
- Animals
- Base Sequence
- DNA Primers
- Ear
- Ganglia, Sensory
- Genotype
- Germ-Line Mutation
- Hair Cells, Auditory, Outer
- Mice
- Mice, Mutant Strains
- Microscopy, Electron
- Molecular Sequence Data
- Neurons, Afferent
- Polymerase Chain Reaction
- Receptor Protein-Tyrosine Kinases
- Receptor, trkB
- Receptor, trkC
- Receptors, Nerve Growth Factor