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Article

Altered phenotype of the vestibular organ in GLAST-1 null mice.

Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2012

Schraven Sebastian P, Franz Christoph, Rüttiger Lukas, Löwenheim Hubert, Lysakowski Anna, Stoffel Wilhelm, Knipper Marlies

Abstract excerpt

Various studies point to a crucial role of the high-affinity sodium-coupled glutamate aspartate transporter GLAST-1 for modulation of excitatory transmission as shown in the retina and the CNS. While 2-4-month-old GLAST-1 null mice did not show any functional vestibular abnormality, we observed profound circling behavior in older (7 months) animals lacking GLAST-1. An unchanged total number of otoferlin-positive...

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Share to Mice, Inbred C57BL
Share to Excitatory Amino Acid Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout

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Source

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Identifiers

PMID: 22350511
DOI: 10.1007/s10162-011-0311-2
PMCID: PMC3346889

Genes

KCNQ4

Provenance

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