Article
Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 1996
Erickson J T, Conover J C, Borday V, Champagnat J, Barbacid M, Yancopoulos G, Katz D M
Abstract excerpt
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT4) act via the TrkB receptor and support survival of primary somatic and visceral sensory neurons. The major visceral sensory population, the nodose-petrosal ganglion complex (NPG), requires BDNF and NT4 for surviv...
Topics
- Alleles
- Animals
- Animals, Newborn
- Brain-Derived Neurotrophic Factor
- Cell Survival
- Mice
- Nerve Growth Factors
- Neurons, Afferent
- Rats
- Rats, Sprague-Dawley
- Respiration Disorders
- Viscera