Article
Relation of body mass index to high on-treatment platelet reactivity and of failed clopidogrel dose adjustment according to platelet reactivity monitoring in patients undergoing percutaneous coronary intervention.
The American journal of cardiology - 1 Dec 2009
Bonello-Palot Nathalie, Armero Sébastien, Paganelli Franck, Mancini Julien, De Labriolle Axel, Bonello Caroline, Lévy Nicolas, Maillard Luc, Barragan Paul, Dignat-George Françoise, Camoin-Jau Laurence, Bonello Laurent
Abstract excerpt
High on-treatment platelet reactivity (HTPR) after a clopidogrel loading dose predicts the risk of thrombotic events after percutaneous coronary intervention. We have demonstrated that HTPR could be overcome in most cases using dose adjustment according to PR monitoring resulting in an improved clinical outcome. However, this strategy failed in nearly 10% of patients with HTPR. Cytochrome P450 (CYP) 2C19...
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