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Article

Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease.

JAMA - 23 Nov 2011

Mega Jessica L, Hochholzer Willibald, Frelinger Andrew L, Kluk Michael J, Angiolillo Dominick J, Kereiakes Dean J, Isserman Steven, Rogers William J, Ruff Christian T, Contant Charles, Pencina Michael J, Scirica Benjamin M, Longtine Janina A, Michelson Alan D, Sabatine Marc S

Abstract excerpt

CONTEXT: Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. OBJECTIVE: To test whether higher doses (up to 300 mg daily) improve the response to clopidogrel in the setting of loss-of-fun...

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Identifiers

PMID: 22088980
DOI: 10.1001/jama.2011.1703

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VASP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22088980-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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