Article
High doses of clopidogrel to overcome genetic resistance: the randomized crossover CLOVIS-2 (Clopidogrel and Response Variability Investigation Study 2).
JACC. Cardiovascular interventions - 1 Apr 2011
Collet Jean-Philippe, Hulot Jean-Sébastien, Anzaha Ghalia, Pena Ana, Chastre Thomas, Caron Claire, Silvain Johanne, Cayla Guillaume, Bellemain-Appaix Anne, Vignalou Jean-Baptiste, Galier Sophie, Barthélémy Olivier, Beygui Farzin, Gallois Vanessa, Montalescot Gilles
Abstract excerpt
OBJECTIVES: This study sought to determine whether the pharmacokinetic (PK) and pharmacodynamic (PD) responses to high or standard clopidogrel loading doses (LDs) differ according to CYP2C19*2 allele. BACKGROUND: CYP2C19 loss-of-function alleles are associated with reduced responsiveness to standard clopidogrel doses. METHODS: Young post-myocardial infarction patients heterozygous (wild type [wt]/*2, n = 43) or...
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