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Article

Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.

Medicina (Kaunas, Lithuania) - 1 Jan 2014

Latkovskis Gustavs, Urtane Inga, Knipse Agnese, Peculis Raitis, Cakstina Inese, Klovins Janis, Erglis Andrejs

Abstract excerpt

BACKGROUND AND OBJECTIVE: Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy. MATERIALS AND METHODS: We enrolled 118 patients undergoing elective or acute percutaneous coronary intervention...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25060201
DOI: 10.1016/j.medici.2014.05.004

Genes

ABCB1
DES
VASP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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