Article
Pilot study of the antiplatelet effect of increased clopidogrel maintenance dosing and its relationship to CYP2C19 genotype in patients with high on-treatment reactivity.
JACC. Cardiovascular interventions - 1 Oct 2010
Barker Colin M, Murray Sarah S, Teirstein Paul S, Kandzari David E, Topol Eric J, Price Matthew J
Abstract excerpt
OBJECTIVES: The objective of this study was to evaluate the antiplatelet effect of clopidogrel 150 mg/day in patients with high on-treatment reactivity (OTR) and to further assess this effect according to CYP2C19 genotype. BACKGROUND: High OTR is associated with ischemic events in clopidogrel-treated patients after percutaneous coronary intervention. Alternative dosing regimens might enhance platelet inhibition....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.