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Article

Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism.

Journal of the American College of Cardiology - 9 Nov 2010

Bonello Laurent, Armero Sébastien, Ait Mokhtar Omar, Mancini Julien, Aldebert Philippe, Saut Noémie, Bonello Nathalie, Barragan Paul, Arques Stéphane, Giacomoni Marie-Paule, Bonello-Burignat Caroline, Bartholomei Marie-Noelle, Dignat-George Françoise, Camoin-Jau Laurence, Paganelli Franck

Abstract excerpt

OBJECTIVES: We aimed to investigate the biological impact of a tailored clopidogrel loading dose (LD) according to platelet reactivity monitoring in carriers of the cytochrome (CYP) 2C19*2 loss-of-function polymorphism undergoing percutaneous coronary intervention for an acute coronary syndromes. BACKGROUND: CYP2C19*2 polymorphism is associated with reduced clopidogrel metabolism and a worse prognosis after...

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Identifiers

PMID: 20708365
DOI: 10.1016/j.jacc.2010.07.004

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VASP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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