Article
Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients.
Thrombosis research - 1 Apr 2010
Bonello Laurent, Bonello-Palot Nathalie, Armero Sébastien, Bonello Caroline, Mokhtar Omar Ait, Arques Stéphane, Dignat-George Françoise, Camoin-Jau Laurence, Paganelli Franck
Abstract excerpt
INTRODUCTION: High on-treatment platelet reactivity (HTPR) after clopidogrel loading dose (LD) is associated with a high risk of thrombotic events after percutaneous coronary intervention(PCI). We have demonstrated that HTPR could be overcome in the majority of cases using LD adjustment resulting in an improved clinical outcome. However this strategy failed in nearly 10% of patients with HTPR. We aimed to...
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