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Article

PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart.

PloS one - 1 Jan 2015

Quan Chao, Xie Bingxian, Wang Hong Yu, Chen Shuai

Abstract excerpt

The Rab GTPase activating protein (RabGAP), AS160/TBC1D4, is an important substrate of protein kinase B (PKB), and regulates insulin-stimulated trafficking of glucose transporter 4. Besides, AS160/TBC1D4 has also been shown to regulate trafficking of many other membrane proteins including FA translocase/CD36 in cardiomyocytes. However, it is not clear whether it plays any role in regulating heart functions in...

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Identifiers

PMID: 25923736
DOI: 10.1371/journal.pone.0124491
PMCID: PMC4414484

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