Comparing apples and oranges: equating the power of case-control and quantitative trait association studies.

Abstract excerpt

Genome-wide association studies have achieved unprecedented success in the identification of novel genes and pathways implicated in complex traits. Typically, studies for disease use a case-control (CC) design and studies for quantitative traits (QT) are population based. The question that we address is what is the equivalence between CC and QT association studies in terms of detection power and sample size? We...

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