Article
A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.
Genetic epidemiology - 1 Dec 2015
Asimit Jennifer L, Panoutsopoulou Kalliope, Wheeler Eleanor, Berndt Sonja I, Cordell Heather J, Morris Andrew P, Zeggini Eleftheria, Barroso Inês
Abstract excerpt
Diseases often cooccur in individuals more often than expected by chance, and may be explained by shared underlying genetic etiology. A common approach to genetic overlap analyses is to use summary genome-wide association study data to identify single-nucleotide polymorphisms (SNPs) that are associated with multiple traits at a selected P-value threshold. However, P-values do not account for differences in power,...
Topics
- Bayes Theorem
- Body Mass Index
- Computer Simulation
- Data Interpretation, Statistical
- Genome-Wide Association Study
- Humans
- Models, Genetic
- Obesity
- Osteoarthritis
- Phenotype
- Polymorphism, Single Nucleotide
- Probability
- Quantitative Trait, Heritable