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Power comparison of Cochran-Armitage trend test against allelic and genotypic tests in large-scale case-control genetic association studies.

Statistical methods in medical research - 1 Sept 2018

Emily Mathieu

Abstract excerpt

The Cochran-Armitage trend test (CA) has become a standard procedure for association testing in large-scale genome-wide association studies (GWAS). However, when the disease model is unknown, there is no consensus on the most powerful test to be used between CA, allelic, and genotypic tests. In this article, we tackle the question of whether CA is best suited to single-locus scanning in GWAS and propose a power...

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PMID: 28008794
DOI: 10.1177/0962280216683979

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