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Method to estimate the approximate samples size that yield a certain number of significant GWAS signals in polygenic traits.

Genetic epidemiology - 1 Jul 2018

Bacanu Silviu-Alin, Kendler Kenneth S

Abstract excerpt

To argue for increased sample collection for disorders without significant findings, researchers resorted to plotting, for multiple traits, the number of significant findings as a function of the sample size. However, for polygenic traits, the prevalence of the disorder confounds the relationship between the number of significant findings and the sample size. To adjust the number of significant findings for...

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PMID: 29761553
DOI: 10.1002/gepi.22125

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