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Article

The statistical power of genome-wide association studies for threshold traits with different frequencies of causal variants.

Genetica - 1 Feb 2022

Khanzadeh Hassan, Ghavi Hossein-Zadeh Navid, Ghovvati Shahrokh

Abstract excerpt

This study aimed to investigate the effects of incidence rate, heritability, and polygenic variance on the statistical power of genome-wide association studies (GWAS) for threshold traits. Different incidence rates of threshold trait (1, 3, 5, 10, 25, 40, 50, 60, 75 and 90%), heritability (10 and 25%), and polygenic variance ratio (0 and 25%) were simulated separately for common (MAF ≥ 0.05), low-frequency...

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PMID: 34705138
DOI: 10.1007/s10709-021-00140-8

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