Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between blood mitochondrial DNA copy number and mental disorders: A bidirectional two-sample mendelian randomization study.

Journal of affective disorders - 1 Dec 2024

Lu Yan'e, Han Lei, Wang Xingxing, Liu Xiaotong, Jia Xinlei, Lan Kunyi, Gao Shumin, Feng Zhendong, Yu Lulu, Yang Qian, Cui Naixue, Wei Ya Bin, Liu Jia Jia

Abstract excerpt

BACKGROUND: Mitochondria is essential for cellular energy production, oxidative stress, and apoptosis. Mitochondrial DNA (mtDNA) encodes essential proteins for mitochondrial function. Although several studies have explored the association between changes in mtDNA copy number (mtDNA-CN) and risk of mental disorders, the results remain debated. This study used a bidirectional two-sample Mendelian randomization (MR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Copy Number Variations
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Mental Disorders

Source

Identifiers

PMID: 39197553
DOI: 10.1016/j.jad.2024.08.162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between blood mitochondrial DNA copy number and mental disorders: A bidirectional two-sample mendelian randomization study.PMID 39197553Read ↗

The role of mitochondrial DNA copy number in neuropsychiatric disorders: A bidirectional two-sample Mendelian randomization studySemantic proximity Read ↗

Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.Semantic proximity Read ↗

The role of mitochondrial DNA copy number in autoimmune disease: a bidirectional two sample mendelian randomization study.Semantic proximity Read ↗

Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.Semantic proximity Read ↗

Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study.Semantic proximity Read ↗

Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseasesSemantic proximity Read ↗

Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization studySemantic proximity Read ↗

Mitochondrial DNA Copy Number and Risk of Gestational Metabolic Disorders: A Two-Sample Mendelian Randomization Study.Semantic proximity Read ↗

Mitochondrial DNA copy number and the risk of autoimmune diseases: A Mendelian randomization study with meta-analysisSemantic proximity Read ↗

Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder.Semantic proximity Read ↗

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.Semantic proximity Read ↗

No Association Between Autism Spectrum Disorder and Mitochondrial DNA Variants: A Comprehensive Genetic Study in Trakya Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.