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Article

Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.

PloS one - 12 Nov 2009

de Vries Hilbert S, Plantinga Theo S, van Krieken J Han, Stienstra Rinke, van Bodegraven Ad A, Festen Eleonora A M, Weersma Rinse K, Crusius J Bart A, Linskens Ronald K, Joosten Leo A B, Netea Mihai G, de Jong Dirk J

Abstract excerpt

BACKGROUND: Dectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes beta-1,3 glucan, a polysaccharide and major component of the fungal cell wall. Upon activation, dectin-1 signaling converges, similar to NOD2, on the adaptor molecule CARD9 which i...

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Source

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Identifiers

PMID: 19915667
DOI: 10.1371/journal.pone.0007818
PMCID: PMC2771910

Genes

NOD2
CARD9
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19915667-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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