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Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

10 Aug 2010

Abstract excerpt

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene...

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PMID: 20700596
DOI: 10.1007/s00335-010-9277-3

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