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Article

Genetics of the innate immune response in inflammatory bowel disease.

Inflammatory bowel diseases - 1 Mar 2007

Van Limbergen Johan, Russell Richard K, Nimmo Elaine R, Ho Gwo-Tzer, Arnott Ian D, Wilson David C, Satsangi Jack

Abstract excerpt

The discovery of nucleotide-binding oligomerization domain 2/caspase recruitment domain-containing protein 15 (NOD2/CARD15) as the first susceptibility gene in Crohn's disease (CD) has shifted the focus of research into the pathogenesis of inflammatory bowel disease (IBD) firmly to the innate immune response and the integrity of the epithelial barrier. The subsequent implication in IBD of variant alleles of OCTN,...

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Source

Identifiers

PMID: 17206667
DOI: 10.1002/ibd.20096

Genes

DLG5
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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