Article
Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.
Inflammatory bowel diseases - 1 Jan 2006
Pierik Marie, Joossens Sofie, Van Steen Kristel, Van Schuerbeek Nele, Vlietinck Robert, Rutgeerts Paul, Vermeire Severine
Abstract excerpt
BACKGROUND: Evidence that a deficient innate immune response toward the bacterial flora of the gut plays a role in the pathogenesis of inflammatory bowel disease (IBD) is growing. This is underscored by the finding of the association between CARD15 variants and Crohn's disease (CD) and D299G in Toll-like receptor (TLR) 4 and IBD. Our aims were to study nonsynonymous polymorphisms in other TLR genes in IBD....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.