Article
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.
Inflammatory bowel diseases - 1 Jul 2005
Brand Stephan, Staudinger Tanja, Schnitzler Fabian, Pfennig Simone, Hofbauer Katrin, Dambacher Julia, Seiderer Julia, Tillack Cornelia, Konrad Astrid, Crispin Alexander, Göke Burkhard, Lohse Peter, Ochsenkühn Thomas
Abstract excerpt
BACKGROUND: We investigated the influence of 2 common Toll-like receptor 4 (TLR4) polymorphisms on susceptibility and disease characteristics of Crohn's disease (CD). METHODS: Genomic DNA from 204 patients with CD and 199 unrelated controls was analyzed for the presence of 2 single nucleotide polymorphisms in the TLR4 gene, resulting in the amino acid substitutions Asp299Gly and Thr399Ile. In addition, the...
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