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Article

Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.

The Journal of infectious diseases - 1 Oct 2011

Rosentul Diana C, Plantinga Theo S, Oosting Marije, Scott William K, Velez Edwards Digna R, Smith P Brian, Alexander Barbara D, Yang John C, Laird Gregory M, Joosten Leo A B, van der Meer Jos W M, Perfect John R, Kullberg Bart-Jan, Netea Mihai G, Johnson Melissa D

Abstract excerpt

BACKGROUND: Candidemia is an important cause of morbidity and mortality in critically ill patients or patients undergoing invasive treatments. Dectin-1 is the main β-glucan receptor, and patients with a complete deficiency of either dectin-1 or its adaptor molecule CARD9 display persistent mucosal infections with Candida albicans. The role of genetic variation of DECTIN-1 and CARD9 genes on the susceptibility to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21881131
DOI: 10.1093/infdis/jir458
PMCID: PMC3164426

Genes

CARD9

Variants

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