Article
Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases.
European journal of gastroenterology & hepatology - 1 Aug 2012
Wolfkamp Simone C S, Verstege Marleen I, Vogels Esther W M, Meisner Sander, Verseijden Caroline, Stokkers Pieter C F, te Velde Anje A
Abstract excerpt
BACKGROUND AND AIM: The balance between microbes and host defence mechanisms at the mucosal frontier plays an important, yet unclarified role in the pathogenesis of inflammatory bowel disease (IBD). The importance of microorganisms in IBD is supported by the association of IBD with mutations in pattern recognition receptors (PRRs) such as NOD2 and TLR4. We aimed to examine whether polymorphisms in another type of...
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