Article
p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.
The American journal of pathology - 1 Oct 1995
DiGiuseppe J A, Redston M S, Yeo C J, Kern S E, Hruban R H
Abstract excerpt
The p53 tumor suppressor gene is mutated in the majority of pancreatic adenocarcinomas, and several studies have suggested that loss of p53 function may contribute to the aggressive clinical behavior of pancreas cancer. Although immunocytochemical accumulation of the p53 gene product has previously been assessed as a marker for p53 mutations in cancers of the pancreas and other organ systems, the relationship...
Topics
- Adenocarcinoma
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme Inhibitors
- Genes, p53
- Humans
- Immunohistochemistry
- Mutation
- Pancreatic Neoplasms
- Tumor Suppressor Protein p53