Article
Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.
Cancer letters - 8 Dec 2008
Chen Jinyun, Killary Ann M, Sen Subrata, Amos Christopher I, Evans Douglas B, Abbruzzese James L, Frazier Marsha L
Abstract excerpt
p21 and p27, members of the kinase inhibitor protein (KIP) family, bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell cycle arrest. The purpose of our study was to identify whether the p21 (C-to-A), and p27 (T-to-G) polymorphisms were associated with age at diagnosis of pancreatic cancer, either independently or jointly. Two hundred and five patients with a diagnosis of pancreatic...
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