A novel tri-allelic insertion/deletion polymorphism in the promoter of p21(Waf1/Cip1) and the association with gastric cancer.

doi:10.1089/gtmb.2013.0375

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Article

A novel tri-allelic insertion/deletion polymorphism in the promoter of p21(Waf1/Cip1) and the association with gastric cancer.

Genetic testing and molecular biomarkers - 1 Feb 2014

Chen Zhiqiang, Dong Ying, Wang Ningju, Liang Hanmei, Du Yong, Ye Xiaofeng, Jia Wei, He Zhongyi, Jiang Yideng, Yang Yinxue, Yang Wenjun

Abstract excerpt

AIMS: p21(Waf1/Cip1) is a cyclin-dependent kinase inhibitor that is pivotal in arresting cellular growth in terminal cell differentiation and apoptosis. Thus, the existence of natural variants of p21(Waf1/Cip1) could be linked to specific cancer. The purpose of this report was to identify a novel tri-allelic insertion/deletion (INDEL) polymorphism (rs4135235) involving a poly-T sequence in the promoter region of...

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Identifiers

PMID: 24387689
DOI: 10.1089/gtmb.2013.0375
PMCID: PMC3926157

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