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Article

Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women.

International journal of cancer - 1 Nov 2006

Ma Hongxia, Jin Guangfu, Hu Zhibin, Zhai Xiangjun, Chen Wensen, Wang Shui, Wang Xuechen, Qin Jianwei, Gao Jun, Liu Jiyong, Wang Xinru, Wei Qingyi, Shen Hongbing

Abstract excerpt

p21(Cip1) and p27(Kip1) are cyclin-dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. Reduced protein expression of p21(Cip1) and p27(Kip1) was frequently observed in a subset of cancers, including breast cancer. In this study, we hypothesized that genetic variants in CDKN1A (encode for p21(Cip1)) and CDKN1B (encode for p27(Kip1)) may modulate the risk of breast...

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Identifiers

PMID: 16804901
DOI: 10.1002/ijc.22094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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