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Article

Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in Chinese liver transplant patients.

Journal of clinical pharmacy and therapeutics - 1 Dec 2017

Chen B, Shi H-Q, Liu X-X, Zhang W-X, Lu J-Q, Xu B-M, Chen H

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVES: Tacrolimus (TAC) is widely used as part of immunosuppressive regimens. There is great interindividual variation on the disposition of TAC. The aim of this study was to develop a population pharmacokinetic (PPK) model for Chinese liver transplant patients and evaluate genetic polymorphism and other possible factors on the PK parameters. The exposure of TAC is to be estimated through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28833329
DOI: 10.1111/jcpt.12599

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ABCB1

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